Available July 1 for Aquifer Curricular Partners

In collaboration with:

International Association of Medical Science Educators

IAMSE logo

 Integrated Illness Scripts are designed specifically to promote cognitive integration and provide a framework for learners to link basic science and clinical knowledge. Building on the traditional illness script format, Integrated Illness Scripts (IIS) embed basic science core concepts and causal mechanisms within each clinical feature and display the connections visually through Mechanism of Disease Maps.



“Thinking Slow More Quickly: Development of Integrated Illness Scripts to Support Cognitively Integrated Learning and Improve Clinical Decision-Making”

Medical Science Educator; May 4, 2021

White Paper:

“Fostering Cognitive Integration & Unpacking Expertise: The Need for Integrated Illness Scripts in Medical and Health Professions Education”

Making Connections for Deeper Understanding & Better Clinical Decisions

Bringing together clinical features, epidemiology, and basic science causal mechanisms and core concepts, Integrated Illness Scripts provides a new mental model for advancing cognitive integration in learners and unpacking encapsulated expertise from faculty. This new framework is designed to enable more effective and efficient clinical decision-making.

Designed for Integration

The first tools designed specifically for integrating basic and clinical sciences in a variety of learning environments.

For Educators, By Educators

Teams of interdisciplinary educators developed and reviewed content that meets the needs of today’s faculty and students.

Nationally Developed Tools

Fully vetted teaching tools provide a framework that can be applied and adapted to fit the needs of your program.

Cognitive integration is a process that occurs in the minds of learners and experts as they interweave relevant basic science and clinical knowledge when reasoning through a patient problem.

Research shows that the effective cognitive integration of basic and clinical science improves diagnostic accuracy, particularly in novice clinicians.

To learn more, we recommend downloading our white paper, “Fostering Cognitive Integration & Unpacking Expertise: The Need for Integrated Illness Scripts in Medical and Health Professions Education.”

Webinar: Integrating Basic Science and Clinical Education: Why It’s Important & Tools to Support You
Webshop – June 22
Creating Mechanism of Disease Maps for Clinical Conditions

Register now for Aquifer’s upcoming interactive webshop on June 22, where Leslie Fall, MD and Amy Wilson-Delfosse, PhD lead a hands-on session focused on how to create Mechanism of Disease to foster integration of basic science and clinical education. Spaces are limited, so make sure to reserve yours today!


The Aquifer Sciences Integrated Illness Scripts were created through a national, multi-institution authoring project. Following a national Call for Participation, teams from six schools were selected to draft Integrated Illness Scripts on common conditions seen in core rotations, leveraging the Aquifer Sciences Open Curriculum Database. Teams at each institution included clinician educators, basic science faculty, and medical students.

Integrated Illness Script Authoring Schools:

  • Albert Einstein College of Medicine
  • Case Western Reserve University School of Medicine
  • Loma Linda University School of Medicine
  • Philadelphia College of Osteopathic Medicine
  • University of Utah School of Medicine
  • Western Michigan University Homer Stryker MD School of Medicine
Peer Review Process

Following the completion of the authoring process, each script underwent an extensive peer review process that included subject experts from the Aquifer Sciences Leadership Team and the:

  • Curriculum Editorial Board (11 basic science faculty members, each representing a different discipline)
  • Clinical Education Consultants (6 interdisciplinary clinical faculty members)

Aquifer is grateful for the hard work of all of our contributors on this project and looks forward to making these important new teaching and learning tools available.

Accessing Integrated Illness Scripts

On July 1, 2021, Aquifer Curricular Partner programs will enjoy free access to:

  • A beta set of 20+ Integrated Illness Scripts, targeted to cover key common conditions students will encounter in their core clinical rotations
  • Ready to use Active Learning Sessions for your classroom and an Integrated Illness Script Educator Guide (details coming soon)
  • ABO Hemolytic Disease of the Newborn
  • Jaundice – Breastfeeding
  • Jaundice – Physiologic
  • Appendicitis
  • Crohn’s Disease
  • Ulcerative Colitis
  • Asthma
  • Pneumonia
  • Pneumothorax
  • Pulmonary Embolism
  • Diabetes – Type 1
  • Diabetes – Type 2
  • Diabetic Ketoacidosis (DKA)
  • Gastroesophageal Reflux Disease (GERD)
  • Myocardial Infarction
  • Shock – Septic
  • Shock – Hypovolemic
  • Shock – Cardiogenic
  • Stroke – Ischemic
  • Stroke – Hemorrhagic
  • Transient Ischemic Attack (TIA)

Aquifer Curricular Partners are programs that subscribe to all five subscription-based Aquifer signature courses.

Anatomy of An Integrated Illness Script

A live demo of an Integrated Illness Script is now available. To access the demo, you can either register for free access or sign in using your Aquifer account. Click on the button below to get started.


For each condition, Integrated Illness Scripts include:

Overview – Epidemiology – Clinical Features (up to 6) – Implications for Further Work Up – Implications for Management – Mechanism of Disease Maps


This section provides the public health context of the condition, covering gender, peak incidence, risk factors, and predisposing conditions related to this diagnosis.

Clinical Features (Up to 6)

For the given diagnosis, the Integrated Illness Script includes six prototypical clinical features seen commonly in patients with this condition.

Within each clinical feature, the Integrated Illness Script describes the underlying basic science causal mechanisms that explain why a patient with that diagnosis displays that clinical finding.

Implications for Management & Further Work Up

These sections provide students an opportunity to reflect and take notes on how this knowledge will influence their clinical practice in diagnosing and treating a patient with this condition.

Mechanism of Disease Maps

Mechanism of Disease Maps trace the steps of pathophysiologic mechanisms from the underlying causes of disease to the observable and measurable clinical signs and symptoms.

Providing a visual representation of the relationship between the “original insult”, key findings, clinical features, and the basic science mechanisms, MOD Maps enable students to see and integrate a more holistic view of the basic science knowledge relevant to the given condition.

Using Integrated Illness Scripts

Aquifer Integrated Illness Scripts are designed to be used in a variety of learning settings, from the classroom to the clinic.

Aquifer Sciences Leadership Team